Creación de un cromosoma sintético en una célula de levadura

En general, la genética se utiliza para mirar hacia atrás: observamos un efecto fenotípico, por ejemplo una enfermedad que está presente en un paciente pero no en sus padres o hermanos, y luego tratamos de establecer cuál es la razón genética subyacente de la enfermedad. Esencialmente buscamos regiones del genoma donde el perfil genético del paciente difiera de otros miembros de su familia, pero debido a que los genomas son tan grandes y complejos, la identificación de los genes puede ser muy difícil.

Hoy en día, gracias al uso de las nuevas tecnologías genómicas, la identificación de los genes responsables de una característica es una tarea relativamente sencilla. Sin embargo, la mayoría de los genes no actúan de forma independiente, sino que interactúan entre sí de una manera muy compleja que todavía no entendemos bien y para complicar aún más las cosas también influyen los factores ambientales.

La genómica sintética le da la vuelta a este punto de vista; genera partes de un genoma en un tubo de ensayo para insertarlas en un organismo. En 2010 Craig Venter, uno de los protagonistas de la biología sintética, demostró que podía sintetizar un genoma químicamente e insertarlo en una bacteria recipiente, previamente vaciada de su código genético, dando lugar a una célula viva de origen sintético. El trabajo de Shrinivasan Chandrasegar va un paso más allá.

Con la ayuda de un grupo de estudiantes de la Universidad John Hopkins, ha creado un cromosoma sintético de Saccharomyces cerevisiae (una levadura utilizada en la producción de vino y pan) y lo ha insertado en el organismo original. Esta cepa de levadura es un organismo modelo común que se utiliza en los laboratorios de todo el mundo ya que es fácil de manejar y mantener.

Lo interesante de este cromosoma sintético es que está diseñado de manera que sus partes pueden encenderse y apagarse según se desee, lo que permite un estudio mucho más profundo de las interacciones entre los diferentes elementos funcionales del cromosoma.

El trabajo prueba que la inserción de cromosomas funcionales en un organismo superior es posible sin poner en peligro su viabilidad. Su plan a largo plazo es reemplazar todos los cromosomas de levadura por equivalentes sintéticos para conseguir un sistema en el que las piezas se puedan encender y apagar a voluntad, con el fin de obtener una mejor comprensión de cómo funcionan unos sistemas tan complejos como los genomas.

El estudio es especialmente interesante ya que puede implicar un beneficio para la investigación de las enfermedades humanas ya que actualmente la comprensión de cómo los genes interactúan se basa en estudios con este tipo de levadura.

Fuente: www.elmundo.es

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  88. {Tôi hạnh phúc hơn cả vui để tìm thấy trang web này. Tôi cần cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thích từng của nó và tôi cũng đã lưu làm mục ưa thích để xem những thứ mới trên blog của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để khám phá một người thực sự hiểu họ là gì đang nói về trên web. Bạn chắc chắn biết cách đưa một rắc rối ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa phải đọc điều này và hiểu khía cạnh này của. Tôi đã ngạc nhiên bạn không nổi tiếng hơn vì bạn chắc chắn sở hữu món quà.|Tốt bài viết trên blog. Tôi hoàn toàn đánh giá cao trang web này. Tiếp tục làm tốt!|Thật gần như không thể tìm thấy những người có kinh nghiệm về điều này, tuy nhiên, bạn nghe có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên tham gia một cuộc thi dành cho một trang web trên web tốt nhất. Tôi sẽ Rất khuyến nghị trang web này!|Một động lực chắc chắn đáng giá bình luận. Tôi nghĩ rằng bạn nên xuất bản thêm về chủ đề này, nó có thể không là một điều cấm kỵ vấn đề nhưng nói chung mọi người không thảo luận những chủ đề như vậy. Đến phần tiếp theo! Chúc mọi điều tốt đẹp nhất.|Chào bạn! Tôi chỉ muốn đề nghị rất cho thông tin xuất sắc bạn có ở đây trên bài đăng này. Tôi sẽ là trở lại blog của bạn để biết thêm thông tin sớm nhất.|Khi tôi ban đầu bình luận tôi có vẻ như đã nhấp hộp kiểm -Thông báo cho tôi khi có bình luận mới- và bây giờ mỗi lần được thêm vào tôi nhận được bốn email cùng chính xác một bình luận. Có lẽ có một cách bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm kích.|Lần sau Tôi đọc một blog, Hy vọng rằng nó sẽ không làm tôi thất vọng nhiều như bài này. Ý tôi là, Tôi biết điều đó là sự lựa chọn của tôi để đọc, dù sao thì tôi thực sự nghĩ có lẽ có điều gì đó hữu ích để nói. Tất cả những gì tôi nghe được là một loạt khóc lóc về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi thực sự tin rằng trang web này cần nhiều hơn nữa sự chú ý.

  89. {Tôi rất hài lòng khám phá trang web này. Tôi muốn cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thích thú từng một phần nó và tôi cũng đã đã đánh dấu trang để xem điều mới trong trang web của bạn.|Tôi có thể chỉ nói rằng thật nhẹ nhõm để khám phá một người mà thực sự hiểu họ là gì thảo luận trên mạng. Bạn thực sự biết cách đưa một vấn đề ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa thực sự cần xem điều này và hiểu khía cạnh này câu chuyện của bạn. Tôi đã ngạc nhiên rằng bạn không nổi tiếng hơn vì bạn chắc chắn sở hữu món quà.|Xuất sắc bài viết trên blog. Tôi hoàn toàn đánh giá cao trang web này. Tiếp tục với nó!|Thật khó đến những người có hiểu biết sâu rộng trong chủ đề cụ thể này, tuy nhiên, bạn có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên là một phần của một cuộc thi dành cho một blog trên internet hữu ích nhất. Tôi chắc chắn sẽ khuyến nghị trang web này!|Một cuộc thảo luận thú vị chắc chắn đáng giá bình luận. Tôi tin rằng bạn cần viết thêm về chủ đề này, nó có thể không là một điều cấm kỵ chủ đề nhưng nói chung mọi người không nói về những chủ đề như vậy. Đến phần tiếp theo! Cảm ơn rất nhiều.|Xin chào! Tôi chỉ muốn cho bạn một rất cho thông tin tuyệt vời bạn có ở đây trên bài đăng này. Tôi sẽ là trở lại trang web của bạn để biết thêm thông tin sớm nhất.|Khi tôi ban đầu để lại bình luận tôi có vẻ như đã nhấp vào hộp kiểm -Thông báo cho tôi khi có bình luận mới- và bây giờ bất cứ khi nào có bình luận được thêm vào tôi nhận được 4 email có cùng nội dung. Có lẽ có một phương tiện bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm ơn bạn.|Lần sau nữa Tôi đọc một blog, Tôi hy vọng rằng nó sẽ không thất bại nhiều như bài này. Ý tôi là, Tôi biết điều đó là sự lựa chọn của tôi để đọc, nhưng tôi thực sự nghĩ bạn sẽ có điều gì đó hữu ích để nói. Tất cả những gì tôi nghe được là một loạt rên rỉ về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi nghiêm túc tin rằng trang web này cần nhiều hơn nữa sự chú ý.

  90. {Tôi khá hài lòng để tìm thấy trang web này. Tôi muốn cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thực sự thích từng của nó và tôi đã đánh dấu để xem thông tin mới trong blog của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để khám phá một người mà thực sự hiểu họ là gì đang nói về trên mạng. Bạn chắc chắn nhận ra cách đưa một vấn đề ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa thực sự cần kiểm tra điều này và hiểu khía cạnh này câu chuyện của bạn. Tôi đã ngạc nhiên rằng bạn không nổi tiếng hơn cho rằng bạn chắc chắn có món quà.|Rất tốt bài viết. Tôi hoàn toàn đánh giá cao trang web này. Tiếp tục làm tốt!|Thật gần như không thể tìm thấy những người hiểu biết trong chủ đề cụ thể này, nhưng bạn nghe có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên là một phần của một cuộc thi dành cho một trang web trực tuyến tuyệt vời nhất. Tôi sẽ Rất khuyến nghị blog này!|Một động lực chắc chắn đáng giá bình luận. Tôi nghĩ rằng bạn nên viết thêm về chủ đề này, nó có thể không là một điều cấm kỵ chủ đề nhưng điển hình mọi người không nói về những chủ đề như vậy. Đến phần tiếp theo! Chúc mọi điều tốt đẹp nhất.|Xin chào! Tôi chỉ muốn đề nghị rất cho thông tin xuất sắc bạn có ngay tại đây trên bài đăng này. Tôi đang trở lại blog của bạn để biết thêm thông tin sớm nhất.|Sau khi tôi ban đầu để lại bình luận tôi có vẻ như đã nhấp hộp kiểm -Thông báo cho tôi khi có bình luận mới- và bây giờ mỗi lần được thêm vào tôi nhận được bốn email cùng chính xác một bình luận. Có lẽ có một phương pháp dễ dàng bạn có thể xóa tôi khỏi dịch vụ đó không? Kudos.|Lần sau Tôi đọc một blog, Tôi hy vọng rằng nó sẽ không làm tôi thất vọng nhiều như bài này. Rốt cuộc, Vâng, đó là sự lựa chọn của tôi để đọc hết, nhưng tôi thực sự tin bạn sẽ có điều gì đó hữu ích để nói. Tất cả những gì tôi nghe được là một loạt rên rỉ về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi nghiêm túc tin rằng trang web này cần nhiều hơn nữa sự chú ý.

  91. {Tôi rất vui để tìm thấy trang web này. Tôi cần cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thưởng thức từng một chút nó và tôi đã lưu làm mục ưa thích để xem điều mới trên trang web của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để khám phá một cá nhân mà thực sự hiểu họ là gì đang nói về trên internet. Bạn chắc chắn biết cách đưa một vấn đề ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa cần phải đọc điều này và hiểu khía cạnh này của. Thật ngạc nhiên bạn không nổi tiếng hơn vì bạn chắc chắn nhất sở hữu món quà.|Xuất sắc bài viết. Tôi hoàn toàn yêu thích trang web này. Tiếp tục với nó!|Thật gần như không thể tìm thấy những người hiểu biết trong chủ đề cụ thể này, tuy nhiên, bạn nghe có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên là một phần của một cuộc thi dành cho một blog trên mạng có chất lượng cao nhất. Tôi sẽ Rất khuyến nghị blog này!|Một động lực chắc chắn đáng giá bình luận. Tôi nghĩ rằng bạn nên viết thêm về chủ đề này, nó có thể không là một điều cấm kỵ vấn đề nhưng điển hình mọi người không thảo luận những chủ đề những điều này. Đến phần tiếp theo! Trân trọng.|Chào bạn! Tôi chỉ muốn cho bạn một rất cho thông tin tuyệt vời bạn có ở đây trên bài đăng này. Tôi sẽ là quay lại trang web của bạn để biết thêm thông tin sớm nhất.|Sau khi tôi ban đầu để lại bình luận tôi có vẻ như đã nhấp vào hộp kiểm -Thông báo cho tôi khi có bình luận mới- và bây giờ mỗi lần được thêm vào tôi nhận được 4 email có cùng nội dung. Phải có một cách bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm ơn.|Lần sau Tôi đọc một blog, Tôi hy vọng rằng nó sẽ không thất bại nhiều như bài này. Ý tôi là, Tôi biết điều đó là sự lựa chọn của tôi để đọc hết, nhưng tôi thực sự tin bạn sẽ có điều gì đó hữu ích để nói. Tất cả những gì tôi nghe được là một loạt khóc lóc về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi nghiêm túc nghĩ trang web này cần nhiều hơn nữa sự chú ý.

  92. {Tôi đã hạnh phúc hơn cả vui khám phá trang web tuyệt vời này. Tôi muốn cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thưởng thức từng một chút nó và tôi cũng đã đánh dấu để xem điều mới trên trang web của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để khám phá một người mà thực sự biết họ là gì đang nói về trên internet. Bạn chắc chắn nhận ra cách đưa một vấn đề ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa nên đọc điều này và hiểu khía cạnh này của. Tôi đã ngạc nhiên bạn không nổi tiếng hơn vì bạn chắc chắn có món quà.|Rất hay bài viết trên blog. Tôi chắc chắn yêu thích trang web này. Tiếp tục làm tốt!|Thật khó tìm những người hiểu biết cho điều này, tuy nhiên, bạn có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên là một phần của một cuộc thi dành cho một trang web trên mạng tốt nhất. Tôi sẽ Rất khuyến nghị trang web này!|Một hấp dẫn chắc chắn đáng giá bình luận. Tôi nghĩ rằng bạn nên xuất bản thêm về chủ đề này, nó có thể không là một điều cấm kỵ vấn đề nhưng điển hình mọi người không thảo luận vấn đề những điều này. Đến phần tiếp theo! Chúc mọi điều tốt đẹp nhất!|Xin chào! Tôi chỉ muốn đề nghị rất to cho thông tin xuất sắc bạn có ở đây trên bài đăng này. Tôi đang quay lại blog của bạn để biết thêm thông tin sớm nhất.|Sau khi tôi ban đầu để lại bình luận tôi có vẻ như đã nhấp vào hộp kiểm -Thông báo cho tôi khi có bình luận mới- và bây giờ bất cứ khi nào có bình luận được thêm vào tôi nhận được 4 email cùng chính xác một bình luận. Có lẽ có một phương pháp dễ dàng bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm kích.|Lần sau Tôi đọc một blog, Hy vọng rằng nó không thất bại nhiều như bài này. Ý tôi là, Tôi biết điều đó là sự lựa chọn của tôi để đọc, tuy nhiên tôi thực sự tin bạn sẽ có điều gì đó thú vị để nói. Tất cả những gì tôi nghe được là một loạt phàn nàn về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi thành thật tin trang web tuyệt vời này cần nhiều hơn nữa sự chú ý.

  93. {Tôi khá hài lòng khám phá trang này. Tôi muốn cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thực sự thích từng một chút nó và tôi đã đánh dấu để xem những thứ mới trong trang web của bạn.|Tôi có thể chỉ nói rằng thật nhẹ nhõm để tìm thấy một người mà thực sự biết họ là gì đang nói về trực tuyến. Bạn chắc chắn hiểu cách đưa một rắc rối ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn phải đọc điều này và hiểu khía cạnh này câu chuyện của bạn. Tôi đã ngạc nhiên bạn không nổi tiếng hơn cho rằng bạn chắc chắn sở hữu món quà.|Tốt bài viết trên blog. Tôi chắc chắn yêu thích trang web này. Cảm ơn!|Thật khó tìm những người hiểu biết về điều này, nhưng bạn nghe có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên tham gia một cuộc thi dành cho một blog trên mạng tốt nhất. Tôi sẽ Rất khuyến nghị trang web này!|Một động lực chắc chắn đáng giá bình luận. Không còn nghi ngờ gì nữa rằng bạn nên viết thêm về chủ đề này, nó có thể không là một điều cấm kỵ vấn đề nhưng điển hình mọi người không thảo luận vấn đề những điều này. Đến phần tiếp theo! Chúc mọi điều tốt đẹp nhất.|Xin chào! Tôi chỉ muốn cho bạn một rất cho thông tin xuất sắc bạn có ở đây trên bài đăng này. Tôi sẽ là quay lại trang web của bạn để biết thêm thông tin sớm nhất.|Khi tôi ban đầu bình luận tôi có vẻ như đã nhấp hộp kiểm -Thông báo cho tôi khi có bình luận mới- và từ bây giờ bất cứ khi nào có bình luận được thêm vào tôi nhận được 4 email cùng chính xác một bình luận. Có một phương pháp dễ dàng bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm ơn rất nhiều.|Lần sau Tôi đọc một blog, Hy vọng rằng nó không làm tôi thất vọng nhiều như bài này. Rốt cuộc, Vâng, đó là sự lựa chọn của tôi để đọc, dù sao thì tôi thực sự tin có lẽ có điều gì đó thú vị để nói. Tất cả những gì tôi nghe được là một loạt phàn nàn về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi hoàn toàn tin trang web này cần nhiều hơn nữa sự chú ý.

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